Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia

Table 1

Laboratory parameters in the acute phase (2–4 days postoperatively).

Time after treatment	Implant coating	GOT (IU/L)	GPT (IU/L)	LDH (IU/L)	Creatinine (mg/dL)	BUN (mg/dL)
	Control	73.0±17.3	31.0±3.0	851.7±458.1	0.22±0.01	21.1±1.1
2 days	HA	80.3±19.2	30.3±1.5	1316.0±569.5	0.22±0.03	18.6±1.6
	2% AgHA	84.6±9.1	34.0±5.1	1018.0±292.5	0.23±0.01	21.4±1.9
	50% AgHA	67.7±8.3	26.7±1.2	730.3±243.1	0.22±0.02	20.7±2.0
3 days	HA	50.0±7.0	25.7±2.1	394.7±121.6	0.25±0.02	22.0±4.9
	2% AgHA	75.0±6.2	34.7±1.5	681.3±188.6	0.26±0.01	21.4±0.4
	50% AgHA	63.3±2.1	26.7±3.5	562.7±64.9	0.21±0.02	19.4±0.6
4 days	HA	87.3±8.7	31.3±1.2	1125.0±147.8	0.20±0.01	17.8±0.4
	2% AgHA	61.3±11.6	27.0±0.0	409.7±235.3	0.25±0.02	17.6±0.7
	50% AgHA	64.3±3.1	26.0±1.7	725.0±251.2	0.22±0.02	17.9±1.1

Five 10-week-old male Sprague-Dawley rats with no treatment were used as controls. No significant differences were seen between the control group and all comparators.
GOT: glutamic-oxaloacetic transaminase; GPT: glutamic-pyruvic transaminase; LDH: lactate dehydrogenase; BUN: blood urea nitrogen.