BioMed Research International / 2014 / Article / Tab 2

Research Article

Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia

Table 2

Laboratory parameters in the subacute phase (4–12 weeks postoperatively).

Time after treatment Implant coating GOT (IU/L) GPT (IU/L) LDH (IU/L) Creatinine (mg/dL) BUN (mg/dL)

4 weeks Control
(14-week-old)
HA
2% AgHA
50% AgHA

8 weeks Control
(18-week-old)
HA
2% AgHA
50% AgHA

12 weeks Control
(22-week-old)
HA
2% AgHA
50% AgHA

Five 14-, 18-, and 22-week-old male Sprague-Dawley rats with no treatment were used as controls for 4, 8, and 12 weeks, respectively. *Mean GOT levels at 4 weeks differed significantly between controls (14-week-old rats) and the HA group ( ). ** and ***are the mean GOT and LDH levels at 8 weeks that differed significantly between controls (18-week-old rats) and the HA group ( ).
GOT: glutamic-oxaloacetic transaminase; GPT: glutamic-pyruvic transaminase; LDH: lactate dehydrogenase; BUN: blood urea nitrogen.