The Association between Serological Biomarkers and Primary Sjogren’s Syndrome Associated with Peripheral Polyneuropathy

Table 2

Laboratory data of primary Sjogren’s syndrome with or without peripheral neuropathy.

	With neuropathy 𝑁=18	Without neuropathy 𝑁=232	All patients 𝑁=250	𝑃 value	Adjusted OR (95% CI)	𝑃 value
Autoantibody titer on admission
Anti-β2 glycoprotein I	3.6 (2.1–8.2)	1.1 (0–3.5)	1.35 (0–3.68)	0.001	(1.015–1.113)	0.01
Anticardiolipin IgG	6.8 (2.4–9.3)	0 (0–4.1)	0.45 (0–4.3)	0.001
Anticardiolipin IgM	1.7 (0–3.5)	0 (0–1.4)	0 (0–1.6)	0.028
Anti-Ro	240.0 (0.7–240.0)	45.6 (0.5–240.0)	56.65 (0.58–240.0)	0.315
Anti-La	2.9 (0.3–320.0)	0.7 (0.3–15.7)	0.7 (0.3–20.23)	0.183
Anti-RNP	1.0 (0.6–1.9)	1.0 (0–1.8)	1.0 (0–1.8)	0.286
anti-Smith IgG	0.2 (0.1–0.5)	0.2 (0–0.4)	0.2 (0–0.4)	0.104
Anti-scl-70	0.1 (0.1–0.3)	0 (0–0.2)	0.1 (0–0.2)	0.049
Anti-Jo1	0.1 (0–0.2)	0 (0–0.1)	0 (0-0.1)	0.050
Anticentromere IgG	0 (0–85.5)	0 (0-0)	0 (0-0)	0.126
p-ANCA	0.2 (0–0.7)	0 (0-0)	0 (0-0)	0.001	(1.011–3.167)	0.046
c-ANCA	0.3 (0–0.6)	0 (0-0)	0 (0-0)	0.001
ESR (mm/h)	19 (12–29)	27 (14–49)	24.5 (13.25–46.75)	0.181
CRP (ng/L)	1.6 (0.75–3.2)	2.7 (1.2–11.1)	2.6 (0.93–8.98)	0.147
Schirmer’s tests on admission
Right eye	0 (0–1.0)	0.5 (0–10.8)	0 (0–10)	0.05
Left eye	0 (0–1.3)	0 (0–6.5)	0 (0–5.0)	0.259
Saliva production tests	0 (0–0.6)	0 (0–2.7)	0 (0–2.39)	0.221
Unstimulated saliva flow tests	0.1 (0–2.0)	0.2 (0–1.0)	0.16 (0–1.11)	0.994

p-ANCA: perinuclear anti-neutrophil cytoplasmic antibody; c-ANCA: cytoplasmic anti-neutrophil cytoplasmic antibody; I1QR: interquartile range; CI: confidence interval; CRP: C-reactive protein; ESR: sedimentation rate.