Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6

Figure 1

H₂O₂ decreases Sirt6 expression in HUVECs. After human umbilical endothelial cells (HUVECs) were incubated in the absence or presence of 75 𝜇M H₂O₂ for 4 days, Sirt6 protein was measured by Western blot and normalized to control (𝑛=3). Tubulin was used as loading control. ^∗𝑃<0.05 compared to control.