Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6
H2O2 decreases Sirt6 expression in HUVECs. After human umbilical endothelial cells (HUVECs) were incubated in the absence or presence of 75 M H2O2 for 4 days, Sirt6 protein was measured by Western blot and normalized to control (). Tubulin was used as loading control. compared to control.