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BioMed Research International
Volume 2014, Article ID 905680, 9 pages
Research Article

EMMPRIN Expression in Oral Squamous Cell Carcinomas: Correlation with Tumor Proliferation and Patient Survival

1Molecular Oncology Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Higher Institute of Health Sciences, CESPU, 4585-116 Paredes, Portugal
2Medicine and Oral Surgery Department, Higher Institute of Health Sciences, 4585-116 Paredes, Portugal
3Pathology Department, Higher School of Health of Vale do Sousa, 4585-116 Paredes, Portugal
4Differentiation and Cancer Group, Institute of Molecular Pathology and Immunology of the University of Porto, (IPATIMUP), 4200-465 Porto, Portugal
5Stomatology Department, Santo António Hospital, Oporto Hospitalar Centre, 4099-001 Porto, Portugal
6Molecular Pathology and Immunology Department, Institute of Biomedical Sciences Abel Salazar (ICBAS), Porto University, 4050-313 Porto, Portugal
7Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
8Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal

Received 14 February 2014; Revised 28 April 2014; Accepted 5 May 2014; Published 21 May 2014

Academic Editor: Mouldy Sioud

Copyright © 2014 Luís Silva Monteiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of our study was to explore the clinicopathological and prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) expression in oral squamous cell carcinomas (OSCC), and its relation with the proliferative tumor status of OSCC. We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC. Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC. EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%). EMMPRIN overexpression was observed in 56 cases (75.7%). Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors . Overexpression of EMMPRIN was correlated with high Ki-67 expression . In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS) . Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors. The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC. Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.