Research Article

Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions

Figure 3

Examples of (a) deregulated miRNA gene clusters and (b) gene families. (a) Clustered and (b) homologous miRNAs are always consistently upregulated or downregulated in tumor cells, although they can differ in fold change values (log 2) and relative expression levels. miRNAs shown here to have zero change (such as miR-25) are not detected or did not show significant differences between tumor and normal cells.
907420.fig.003a
(a)
907420.fig.003b
(b)