Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions

Table 1

Differences in expression between natural sense and antisense miRNAs.

miRNA/miRNA	The most abundant isomiR		Sum of all isomiRs		The canonical miRNA
	HepG2	L02	HepG2	L02	HepG2	L02
103a/103b	9232/—	1833/—	10639/—	2525/—	9232/—	1833/—
122/3591	163/—	938/—	837/—	3550/—	10/—	17/—
203/3545	—/—	216/—	—/—	705/—	—/—	12/—
24/3074	787/2	14998/—	6618/3	29094/—	3592/—	1597/—
423-5p/3184-3p	1208/—	3159/—	1882/—	5790/—	1208/—	3159/—
423-3p/3184-5p	981/—	5036/1	1934/—	8290/1	981/—	5036/—
7-5p/3529-3p	1132/—	939/—	1931/—	2397/—	238/—	386/—
374b-5p/374c-3p	137/—	67/—	318/—	203/—	137/—	67/—

Based on the different methods of estimation, the most abundant isomiR, sum of all isomiRs, and the canonical miRNA, relative expression levels of these pairs of miRNA pairs were determined. They are presented here using normalized data. One member of each pair was always far more abundantly expressed than the other. “—” indicates an undetectable miRNA.