Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats

Table 2

Histopathologic examination of liver tissue.

	Sinusoid dilatation; (mean ± sd)	Hepatocyte degeneration; (mean ± sd)	Neutrophil infiltration; (mean ± sd)	Antiliver arginase reactivity; (mean ± sd)	Anti-CPS-1 reactivity; (mean ± sd)
Control	0±0	0±0	0±0	3.0±0.8	3.8±0.4
I/R	3.0±0.4^∗,¶	3.1±0.3^∗,A	2.8±0.8^∗,W	2.1±0.8^¥,B	2.0±0.6^∗,¶
I/R + ADA	2.2±0.8^∗	2.2±0.7^∗	1.2±0.4^∗	3.7±0.6	3.0±0.8^X

CPS 1: carbamoyl phosphate synthetase 1; I/R: ischemia/reperfusion; ADA: adalimumab.
For sinusoid dilatation: ^∗𝑃<0.001 versus control group; ^¶𝑃=0.015 versus I/R + ADA group.
For hepatocyte degeneration: ^∗𝑃<0.001 versus control group; ^A𝑃=0.005 versus I/R + ADA group.
For neutrophil infiltration: ^∗𝑃<0.001 versus control group; ^W𝑃<0.001 versus I/R + ADA.
For Antiliver arginase reactivity: ^¥𝑃=0.011 versus control group; ^B𝑃=0.002 versus I/R + ADA.
For Anti-CPS1 reactivity: ^∗𝑃<0.001, ^X𝑃=0.015 versus control group; ^¶𝑃=0.015 versus I/R + ADA group.