BioMed Research International / 2014 / Article / Tab 2

Review Article

Estimating Glomerular Filtration Rate in Older People

Table 2

Equations for estimating renal function.

Cockcroft and Gault [69]eCCr = (140−age) × weight in kg/(72 × Scr), ×0.85 in females

Six-variable MDRD [71]170 * [Scr]−0.999 * age −0.176 * BUN −0.170 * serum albumin 0.318, *0.762 in females, *1.180 if black

Four-variable MDRD [71] 186.3 × (Scr)−1.154  × (age)−0.203 , ×0.742 in females, ×1.212 if black

CKD-EPI (creatinine) [77]Female (Scr ≤ 0.7), eGFR = 144 × (Scr/0.7)−0.329  × (0.993)Age
   (Scr > 0.7), eGFR = 144 × (Scr/0.7)−1.209  × (0.993)Age
Male (Scr ≤ 0.9), eGFR = 141 × (Scr/0.9)−0.411  × (0.993)Age
  (Scr > 0.9), eGFR = 141 × (Scr/0.9)−1.209  × (0.993)Age

CKD-EPI (cystatin C) [80](Scys ≤ 0.8), eGFR = 133 × (Scys/0.8)−0.499  × 0.996Age   ×0.932 if female
(Scys > 0.8), eGFR = 133 × (Scys/0.8)−1.328  × 0.996Age   ×0.932 if female

CKD-EPI (cystatin C-creatinine) [80]Female (Scr ≤ 0.7) (Scys ≤ 0.8), eGFR = 130 × (Scr/0.7)−0.248  × (Scys/0.8)−0.375  × 0.995Age   ×1.08 if black
     (Scr ≤ 0.7) (Scys > 0.8), eGFR = 130 × (Scr/0.7)−0.248  × (Scys/0.8)−0.711  × 0.995Age   ×1.08 if black
Female (Scr > 0.7) (Scys ≤ 0.8), eGFR = 130 × (Scr/0.7)−0.601  × (Scys/0.8)−0.375  × 0.995Age   ×1.08 if black
    (Scr > 0.7) (Scys > 0.8), eGFR = 130 × (Scr/0.7)−0.601  × (Scys/0.8)−0.711  × 0.995Age   ×1.08 if black
Male (Scr ≤ 0.9) (Scys ≤ 0.8), eGFR = 135 × (Scr/0.9)−0.207  × (Scys/0.8)−0.375  × 0.995Age   ×1.08 if black
    (Scr ≤ 0.9) (Scys > 0.8), eGFR = 135 × (Scr/0.9)−0.207  × (Scys/0.8)−0.711  × 0.995Age   ×1.08 if black
Male (Scr > 0.9) (Scys ≤ 0.8), eGFR = 135 × (Scr/0.9)−0.601  × (Scys/0.8)−0.375  × 0.995Age   ×1.08 if black
   (Scr > 0.9) (Scys > 0.8), eGFR = 135 × (Scr/0.9)−0.601  × (Scys/0.8)−0.711  × 0.995Age   ×1.08 if black

BIS1 [81]3736 × creatinine−0.87  × age−0.95  × 0.82 (if female)

BIS2 [81]767 × cystatin C−0.61  × creatinine−0.40  × age−0.57  × 0.87 (if female)

eCCr: estimated creatinine clearance; Scr: serum creatinine; BUN: blood urea nitrogen; Scys: serum cystatin C; MDRD: Modification of Diet in Renal Disease; CKD-EPI: Chronic Kidney Disease Epidemiological Collaboration; BIS: Berlin Initiative Study.

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