Estimating Glomerular Filtration Rate in Older People

Table 2

Equations for estimating renal function.

Cockcroft and Gault [69]	eCCr = (140−age) × weight in kg/(72 × Scr), ×0.85 in females
Six-variable MDRD [71]	170 * [Scr]^−0.999 * [age]^−0.176 * [BUN]^−0.170 * [serum albumin]^0.318, *0.762 in females, *1.180 if black
Four-variable MDRD [71]	[186.3 × (Scr)^−1.154  × (age)^−0.203], ×0.742 in females, ×1.212 if black
CKD-EPI (creatinine) [77]	Female (Scr ≤ 0.7), eGFR = 144 × (Scr/0.7)^−0.329  × (0.993)^Age; (Scr > 0.7), eGFR = 144 × (Scr/0.7)^−1.209  × (0.993)^Age; Male (Scr ≤ 0.9), eGFR = 141 × (Scr/0.9)^−0.411  × (0.993)^Age; (Scr > 0.9), eGFR = 141 × (Scr/0.9)^−1.209  × (0.993)^Age
CKD-EPI (cystatin C) [80]	(Scys ≤ 0.8), eGFR = 133 × (Scys/0.8)^−0.499  × 0.996^Age  [×0.932 if female]; (Scys > 0.8), eGFR = 133 × (Scys/0.8)^−1.328  × 0.996^Age  [×0.932 if female]
CKD-EPI (cystatin C-creatinine) [80]	Female (Scr ≤ 0.7) (Scys ≤ 0.8), eGFR = 130 × (Scr/0.7)^−0.248  × (Scys/0.8)^−0.375  × 0.995^Age  [×1.08 if black]; (Scr ≤ 0.7) (Scys > 0.8), eGFR = 130 × (Scr/0.7)^−0.248  × (Scys/0.8)^−0.711  × 0.995^Age  [×1.08 if black]
	Female (Scr > 0.7) (Scys ≤ 0.8), eGFR = 130 × (Scr/0.7)^−0.601  × (Scys/0.8)^−0.375  × 0.995^Age  [×1.08 if black]; (Scr > 0.7) (Scys > 0.8), eGFR = 130 × (Scr/0.7)^−0.601  × (Scys/0.8)^−0.711  × 0.995^Age  [×1.08 if black]
	Male (Scr ≤ 0.9) (Scys ≤ 0.8), eGFR = 135 × (Scr/0.9)^−0.207  × (Scys/0.8)^−0.375  × 0.995^Age  [×1.08 if black]; (Scr ≤ 0.9) (Scys > 0.8), eGFR = 135 × (Scr/0.9)^−0.207  × (Scys/0.8)^−0.711  × 0.995^Age  [×1.08 if black]
	Male (Scr > 0.9) (Scys ≤ 0.8), eGFR = 135 × (Scr/0.9)^−0.601  × (Scys/0.8)^−0.375  × 0.995^Age  [×1.08 if black]; (Scr > 0.9) (Scys > 0.8), eGFR = 135 × (Scr/0.9)^−0.601  × (Scys/0.8)^−0.711  × 0.995^Age  [×1.08 if black]
BIS1 [81]	3736 × creatinine^−0.87  × age^−0.95  × 0.82 (if female)
BIS2 [81]	767 × cystatin C^−0.61  × creatinine^−0.40  × age^−0.57  × 0.87 (if female)

eCCr: estimated creatinine clearance; Scr: serum creatinine; BUN: blood urea nitrogen; Scys: serum cystatin C; MDRD: Modification of Diet in Renal Disease; CKD-EPI: Chronic Kidney Disease Epidemiological Collaboration; BIS: Berlin Initiative Study.