BioMed Research International / 2014 / Article / Tab 3

Review Article

A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

Table 3

A summary of antihyperlipidemic effects of different TCM formulae.

TCM formulaeHerbs (weight ratio in dose if applicable)Effects mentioned in TCMsEffects on blood lipid profilePossible hypolipidemic mechanisms

Danggui-Buxue decoctionAstragali Radix and Angelicae Sinensis Radix (1 : 5) [153](i) Raising the
(ii) Nourishing the blood [17]
(i) Lowering serum TC and LDL-C levels
(ii) Increasing HDL-C level
(iii) No significant difference in TG level as compared with diabetic atherosclerosis model group [49, 154]
Downregulating the mRNA expression of MCP-1, ICAM-1, and CD36 [49, 154]

Danshen-Gegen formulaSalviae Miltiorrhizae Radix and Puerariae Lobatae Radix (7 : 3) [53](i) Promoting blood circulation
(ii) Removing blood stasis [200]
(i) A significant dose-dependent decrease in free and esterified TC in the human monocyte derived macrophages in vitro [147]
(ii) Lowering TC and LDL-C levels mildly in patients suffering from coronary artery disease compared with placebo [56]
(iii) Lowering TC and LDL levels in postmenopausal women with hypercholesterolemia [52]
Dose-related suppression of acetylated LDL uptake by human macrophages [53]

Erxian decoctionCurculiginis Rhizoma, Epimedii Folium, Angelicae Sinensis Radix, Morindae Officinalis Radix, Anemarrhenae Rhizoma, and Phellodendri Chinensis Cortex (no fixed ratio) [60](i) Warming “kidneyYang
(ii) Nourishing “kidneyYin
(iii) Clearing ministerial fire 
(iv) Harmonizing thoroughfare and conception vessels
(v) Balancing Yin-Yang [60]
(i) Suppressing serum TC and LDL-C levels
(ii) No significant effect on HDL-C and TG levels in a menopausal rat model [54]
(i) Downregulating HMG-CoA
(ii) Upregulating the LDL receptor [54]

Ling-Gui-Zhu-Gan decoctionPoria, Cinnamomi Ramulus, Atractylodis Macrocephalae Rhizoma, and Glycyrrhizae Radix (4 : 3 : 3 : 2) [63](i) Warming Yang for resolving fluid retention
(ii) Strengthening the “spleen” to resolve dampness [63]
(i) Reducing TG and TC levels in HFD induced rat models of NAFLD [57]
(ii) Lowering ghrelin level in HFD rat groups fasting intermittently supplemented with LGZD [63]
(i) Increasing serum thyroid hormone levels [57]
(ii) Improving -oxidation via modulation of TR 1 and CPT1A expression in liver [57]
(iii) Enhancing metabolism and transport of FA through modulation of SREBP-1c, ACSL and ApoB100 expression [57]

Shengmai YinGinseng Radix et Rhizoma, Ophiopogonis Radix, and Schisandra Chinensis Fructus (2 : 1 : 2) [58](i) Replenishing both and Yin energies
(ii) Generating body fluids
(iii) Restoring the pulses [17]
(i) No significant effect on lipids of Wistar rats fed with HCD
(ii) Lowering hepatic cholesterol and TG contents
(iii) No effect on fecal cholesterol excretion but higher fecal bile acid content [59]
(i) Stimulating the biosynthesis of bile acid using cholesterol as the precursor
(ii) Increasing hepatic cholesterol catabolism [59]

Turtle jellyTestudinis Plastrum, plus various Chinese medicinal herbs such as Smilacis Glabrae Rhizoma, Millettiae Speciosae Radix, Mesonae Chinensis Herba, and Lonicerae Japonicae Flos [173](i) Clearing heat
(ii) Removing toxin
(iii) Promoting urination [51]
(i) Lowering serum TC and LDL levels
(ii) Increasing HDL level diet-induced hypercholesterolemic SD rats [50]
(i) Blocking the downregulation of LDLR and PEPCK mRNA and protein expressions
(ii) Suppressing the upregulation of PPARα mRNA and protein expressions in the liver [173]

Xuefu-Zhuyu decoctionBupleuri Chinensis Radix, Angelicae Sinensis Radix, Rehmanniae Radix, Paeoniae Rubra Radix, Carthami Flos, Persicae Semen, Aurantii Fructus Immaturus, Glycyrrhizae Radix, Platycodi Radix, Chuanxiong Rhizoma, and Achyranthis Bidentatae Radix [61](i) Promoting blood circulation to remove blood stasis
(ii) Moving to relieve pain [17]
(i) Lowering serum TC and LDL-C levels
(ii) Increasing HDL-C level
(iii) No significant difference in TG level in HFD fed SD rats as compared with the model group [62]
(iv) Lowering TG level and TC/HDL-C ratio in HCD fed Wistar rats [182]
(i) Reversing energy and lipid metabolism disturbance
(ii) Decreasing the accumulation acetyl-glycoproteins
(iii) Enhancing glutathione biosynthesis [62]
(iv) Inhibiting proinflammatory interleukin 8 production [182]

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