Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 931361, 6 pages
http://dx.doi.org/10.1155/2014/931361
Research Article

The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study

1Departments of Molecular Biology, Endocrinology, and Immunology, National Institute of Cardiology Ignacio Chávez, 14080 Mexico City, DF, Mexico
2Department of Endocrinology, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080 Mexico City, DF, Mexico
3Cardiovascular Genomics Laboratory, National Institute of Genomic Medicine, 14610 Mexico City, DF, Mexico
4Department of Immunology, National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080 Mexico City, DF, Mexico
5Laboratory of Genomic Medicine, Research Unit, Juárez de México Hospital, 07760 Mexico City, DF, Mexico

Received 19 February 2014; Revised 2 May 2014; Accepted 4 May 2014; Published 18 May 2014

Academic Editor: Terry K. Smith

Copyright © 2014 Gilberto Vargas-Alarcón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response. Secretory phospholipase A2-V (sPLA2-V) encoded by PLA2G5 gene promotes diverse proinflammatory processes. The aim of the present study was to analyze if PLA2G5 gene polymorphisms are associated with premature CAD. Three PLA2G5 polymorphisms (rs11573187, rs2148911, and rs11573191) were analyzed in 707 patients with premature CAD and 749 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis. Under dominant, recessive, and additive models, the rs11573191 polymorphism was associated with increased risk of premature CAD (OR = 1.51, Pdom = 3.5 × 10−3; OR = 2.95, Prec = 0.023; OR = 1.51, Padd = 1.2 × 10−3). According to the informatics software, this polymorphism had a functional effect modifying the affinity of the sequence by the MZF1 transcription factor. PLA2G5 polymorphisms were in linkage disequilibrium and the CGA haplotype was associated with increased risk of premature CAD (OR = 1.49, P = 0.0023) and with hypertension in these patients (OR = 1.75, P = 0.0072). Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD. In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD and hypertension.