The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study

Table 3

Association of the rs11573185, rs2148911, and rs11573191 PLA2G5 gene polymorphisms with premature CAD.

rs11573185	Genotype frequency (%)			MAF	Model	OR (95% CI)	𝑃
	A/A	A/C	C/C
Control (𝑛 = 749)	0.410	0.437	0.153	0.371
Premature CAD (𝑛 = 707)	0.395	0.462	0.142	0.373	Dominant; additive	1.21 (0.97–1.52); 1.10 (0.94–1.28)	0.089; 0.250
rs2148911	Genotype frequency (%)			MAF	Model	OR (95% CI)	𝑃
	G/G	G/A	A/A
Control (𝑛 = 749)	0.780	0.206	0.015	0.117
Premature CAD (𝑛 = 707)	0.782	0.203	0.014	0.115	Dominant; additive	1.08 (0.83–1.41); 1.07 (0.84–1.36)	0.560; 0.610
rs11573191	Genotype frequency (%)			MAF	Model	OR (95% CI)	𝑃
	G/G	G/A	A/A
Control (𝑛 = 749)	0.825	0.166	0.009	0.092
Premature CAD (𝑛 = 707)	0.777	0.202	0.021	0.122	Dominant; recessive; additive	1.51 (1.14–1.99); 2.95 (1.12–3.76); 1.51 (1.17–1.94)	3.5 × 10 ^−3; 0.023; 1.2 × 10 ^−3

Associations were tested using logistic regression adjusting for age, gender, and BMI.
CAD: coronary artery disease; MAF: minor allele frequency.