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BioMed Research International
Volume 2014, Article ID 932340, 11 pages
http://dx.doi.org/10.1155/2014/932340
Research Article

p120 Modulates LPS-Induced NF-κB Activation Partially through RhoA in Bronchial Epithelial Cells

Key Laboratory of Pulmonary Disease of Ministry of Health of China, Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

Received 23 January 2014; Revised 22 April 2014; Accepted 8 May 2014; Published 3 June 2014

Academic Editor: Vickram Ramkumar

Copyright © 2014 Lingzhi Qin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Matthay and G. A. Zimmerman, “Acute lung injury and the acute respiratory distress syndrome: Four decades of inquiry into pathogenesis and rational management,” American Journal of Respiratory Cell and Molecular Biology, vol. 33, no. 4, pp. 319–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Hirano, “Quantitative time-course profiles of bronchoalveolar lavage cells following intratracheal instillation of lipopolysaccharide in mice,” Industrial Health, vol. 35, pp. 353–358, 1997. View at Publisher · View at Google Scholar
  3. M. E. Poynter, C. G. Irvin, and Y. M. W. Janssen-Heininger, “A prominent role for airway epithelial NF-κB activation in lipopolysaccharide-induced airway inflammation,” Journal of Immunology, vol. 170, no. 12, pp. 6257–6265, 2003. View at Google Scholar · View at Scopus
  4. E. F. Gillespie, N. Raychaudhuri, K. I. Papageorgiou et al., “Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB,” Investigative Ophthalmology and Visual Science, vol. 53, no. 12, pp. 7746–7753, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Bottex-Gauthier, S. Pollet, A. Favier, and D. R. Vidal, “The Rel/NF-κB family of transcription factors: a complex system for regulatory cell control,” Pathologie Biologie, vol. 50, no. 3, pp. 204–211, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Ghosh, M. J. May, and E. B. Kopp, “NF-κB and rel proteins: evolutionarily conserved mediators of immune responses,” Annual Review of Immunology, vol. 16, pp. 225–260, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. A. B. Reynolds, D. J. Roesel, S. B. Kanner, and J. T. Parsons, “Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene,” Molecular and Cellular Biology, vol. 9, no. 2, pp. 629–638, 1989. View at Google Scholar · View at Scopus
  8. S. Shibamoto, M. Hayakawa, K. Takeuchi et al., “Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes,” Journal of Cell Biology, vol. 128, no. 5, pp. 949–957, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Ferber, C. Yaen, E. Sarmiento, and J. Martinez, “An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation,” Experimental Cell Research, vol. 274, no. 1, pp. 35–44, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Ishiyama, S.-H. Lee, S. Liu et al., “Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion,” Cell, vol. 141, no. 1, pp. 117–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. B. Stairs, L. J. Bayne, B. Rhoades et al., “Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene,” Cancer Cell, vol. 19, no. 4, pp. 470–483, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Perez-Moreno, M. A. Davis, E. Wong, H. A. Pasolli, A. B. Reynolds, and E. Fuchs, “p120-catenin mediates inflammatory responses in the skin,” Cell, vol. 124, no. 3, pp. 631–644, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Perez-Moreno, W. Song, H. A. Pasolli, S. E. Williams, and E. Fuchs, “Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 40, pp. 15399–15404, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Wang, N. Li, J. Li et al., “Involvement of p120 in LPS-induced NF-κB activation and IL-8 production in human bronchial epithelial cells,” Toxicology Letters, vol. 195, no. 1, pp. 75–81, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. W. G. Smalley-Freed, A. Efimov, P. E. Burnett et al., “p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice,” The Journal of Clinical Investigation, vol. 120, no. 6, pp. 1824–1835, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Menke and K. Giehl, “Regulation of adherens junctions by Rho GTPases and p120-catenin,” Archives of Biochemistry and Biophysics, vol. 524, no. 1, pp. 48–55, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. E. E. Evers, G. C. M. Zondag, A. Malliri et al., “Rho family proteins in cell adhesion and cell migration,” European Journal of Cancer, vol. 36, no. 10, pp. 1269–1274, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Z. Anastasiadis and A. B. Reynolds, “Regulation of Rho GTPases by p120-catenin,” Current Opinion in Cell Biology, vol. 13, no. 5, pp. 604–610, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Charrasse, F. Comunale, Y. Grumbach, F. Poulat, A. Blangy, and C. Gauthier-Rouvière, “RhoA GTPase regulates M-cadherin activity and myoblast fusion,” Molecular Biology of the Cell, vol. 17, no. 2, pp. 749–759, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. A. L. Smith, M. R. Dohn, M. V. Brown, and A. B. Reynolds, “Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin,” Molecular Biology of the Cell, vol. 23, no. 1, pp. 99–110, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. G. A. Wildenberg, M. R. Dohn, R. H. Carnahan et al., “p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho,” Cell, vol. 127, no. 5, pp. 1027–1039, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. A. L. Cozens, M. J. Yezzi, K. Kunzelmann et al., “CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 10, no. 1, pp. 38–47, 1994. View at Google Scholar · View at Scopus
  23. Y. Ma, M. Wang, N. Li, R. Wu, and X. Wang, “Bleomycin-induced nuclear factor-κB activation in human bronchial epithelial cells involves the phosphorylation of glycogen synthase kinase 3β,” Toxicology Letters, vol. 187, no. 3, pp. 194–200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Wang, Y. Wang, S. Dai et al., “P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively,” PLoS ONE, vol. 7, no. 1, Article ID e30303, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Z. Anastasiadis, M. Yanagisawa, L. A. Marlow, J. A. Copland, E. A. Perez, and P. Z. Anastasiadis, “p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression,” Journal of Cell Biology, vol. 183, no. 4, pp. 737–749, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. T. A. Tucker, K. Varga, Z. Bebok et al., “Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids,” American Journal of Physiology, Cell Physiology, vol. 284, no. 3, pp. C791–C804, 2003. View at Google Scholar · View at Scopus
  27. Y. Wang, M. Wang, F. Wang et al., “IQGAP1 promotes cell proliferation and is involved in a phosphorylation-dependent manner in wound closure of bronchial epithelial cells,” International Journal of Molecular Medicine, vol. 22, no. 1, pp. 79–87, 2008. View at Google Scholar · View at Scopus
  28. Y.-L. Wang, A. B. Malik, Y. Sun et al., “Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin,” Journal of Immunology, vol. 186, no. 5, pp. 3180–3187, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. I. M. Verma, J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto, “Rel/NF-κB/IκB family: intimate tales of association and dissociation,” Genes and Development, vol. 9, no. 22, pp. 2723–2735, 1995. View at Google Scholar · View at Scopus
  30. X. Xie, J. Peng, X. Chang et al., “Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy,” Molecular and Cellular Endocrinology, vol. 369, no. 1-2, pp. 86–97, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. A. B. Reynolds, “p120-catenin: Past and present,” Biochimica et Biophysica Acta, Molecular Cell Research, vol. 1773, no. 1, pp. 2–7, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. A. B. Reynolds and A. Roczniak-Ferguson, “Emerging roles for p120-catenin in cell adhesion and cancer,” Oncogene, vol. 23, no. 48, pp. 7947–7956, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Keirsebilck, S. Bonné, K. Staes et al., “Molecular cloning of the human p120(ctn) catenin gene (CTNND1): expression of multiple alternatively spliced isoforms,” Genomics, vol. 50, no. 2, pp. 129–146, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. Liu, H.-T. Xu, S.-D. Dai, Q. Wei, X.-M. Yuan, and E.-H. Wang, “Reduction of p120ctn isoforms 1 and 3 is significantly associated with metastatic progression of human lung cancer,” APMIS, vol. 115, no. 7, pp. 848–856, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Paredes, A. L. Correia, A. S. Ribeiro, and F. Schmitt, “Expression of p120-catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines,” Cellular Oncology, vol. 29, no. 6, pp. 467–476, 2007. View at Google Scholar · View at Scopus
  36. R. T. Sadikot, H. Zeng, M. Joo et al., “Targeted immunomodulation of the NF-κB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa,” Journal of Immunology, vol. 176, no. 8, pp. 4923–4930, 2006. View at Google Scholar · View at Scopus
  37. H. Harant, R. de Martin, P. J. Andrew, E. Foglar, C. Dittrich, and I. J. Lindley, “Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumor necrosis factor-α involves the transcription factor NF-κB,” The Journal of Biological Chemistry, vol. 271, pp. 26954–26961, 1996. View at Publisher · View at Google Scholar
  38. P. Z. Anastasiadis, “p120-ctn: a nexus for contextual signaling via Rho GTPases,” Biochimica et Biophysica Acta, Molecular Cell Research, vol. 1773, no. 1, pp. 34–46, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Z. Anastasiadis, S. Y. Moon, M. A. Thoreson et al., “Inhibition of RhoA by p120 catenin,” Nature Cell Biology, vol. 2, no. 9, pp. 637–644, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. I. Grosheva, M. Shtutman, M. Elbaum, and A. D. Bershadsky, “P120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion,” Journal of Cell Science, vol. 114, no. 4, pp. 695–707, 2001. View at Google Scholar · View at Scopus
  41. T. Pieters, J. Van Hengel, and F. Van Roy, “Functions of p120ctn in development and disease,” Frontiers in Bioscience, vol. 17, no. 2, pp. 760–783, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. C. Epifano, D. Megias, and M. Perez-Moreno, “p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals,” EMBO Reports, vol. 15, no. 5, pp. 592–600, 2014. View at Publisher · View at Google Scholar