Isocudraxanthone K Induces Growth Inhibition and Apoptosis in Oral Cancer Cells via Hypoxia Inducible Factor-1α

Figure 3

Effects of isocudraxanthone K (IK) on migration (a, b), invasion (c, d), and colony formation (e, f) in HN4 (a, c, e) and HN12 (b, d, f) cells. Transwell assay kit was employed to evaluate the migratory ability for 2 days. In vitro cell invasion assays were performed using the cell invasion assay kit for 2 days. Cell colony formation was measured using soft agar colony formation assay. The number of colonies was counted at 7 days after seeding the cells. Data are representative of three independent experiments (𝑛=4) and presented as % compared to nonstimulated control cells. ∗Statistically significant difference, compared with control, 𝑃<0.05.

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