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BioMed Research International
Volume 2014, Article ID 934848, 12 pages
http://dx.doi.org/10.1155/2014/934848
Research Article

Proteomics and Metabolomics for In Situ Monitoring of Wound Healing

1Department of Proteomics, Helmholtz-Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany
2University Center of Orthopedics and Trauma Surgery, University Hospital “Carl Gustav Carus”, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany
3Department of Oral and Maxillofacial Surgery, University Hospital “Carl Gustav Carus”, TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany
4Department of Metabolomics, Helmholtz-Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany
5Institute of Pharmacy, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, 04103 Leipzig, Germany
6Institute of Physiological Chemistry, TU Dresden, Fiedlerstraße 42, 01307 Dresden, Germany
7Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, 9000 Aalborg, Denmark

Received 28 February 2014; Revised 3 June 2014; Accepted 4 June 2014; Published 4 August 2014

Academic Editor: Antonio Salgado

Copyright © 2014 Stefan Kalkhof et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: Quantification results of the 163 selected metabolites which were measured in the dialysates of the femoral bone and soft tissue defect.

Table S2: Qualitative, quantitative, and functional information about all proteins being quantified in the dialysates in at least 2 replicates of the femoral bone or soft tissue defect

Table S3: Qualitative, quantitative, and functional information about all proteins being quantified in the adsobates in at least 2 replicates of the femoral bone or soft tissue defect.

Table S4: List of the main gene ontology clusters of (A and C) biological processes, (B) cellular compartments covered by the all identified proteins (A) and all secreted proteins (C).

Table S5: List of the proteins being either reproducible detected in the femoral bone defect but were only covered in maximum one replicate of the soft tissue defect or (ii) which were detected with a more than 10 times altered intensity in bone compared to soft tissue samples.

  1. Supplementary Material