The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma

Table 4

Prognostic factors of esophageal cancer according to multivariate analysis.

Variables	Risk ratio	95% CI	𝑃 value
Location of the primary tumor
Ut-Mt	Ref.	0.861452–2.20629	0.1813
Lt-Ae	1.37267
Lymphatic invasion
Negative	Ref.	1.012886–2.725895	0.0437^∗
Positive	1.605417
Venous invasion
Negative	Ref.	0.954510–2.395284	0.08
Positive	1.483897
pT
pT1	Ref.	1.122531–3.250204	0.0146^∗
pT2-3	1.834223
pN
pN0	Ref.	1.152392–3.450263	0.0110^∗
pN1-3	1.911249
Invasive front
Negative	Ref.	1.357757–4.524146	0.0014^∗
Positive	2.332559

Ut: upper thoracic esophagus; Mt: middle thoracic esophagus; Lt: lower thoracic esophagus; Ae: abdominal esophagus; pT: pathological T stage; pN: pathological N stage; Ref.: referent.
^∗𝑃<0.05: Cox’s proportional hazards model; 95% CI: 95% confidence interval.