Renal Overexpression of Atrial Natriuretic Peptide and Hypoxia Inducible Factor-1 as Adaptive Response to a High Salt Diet

Figure 4

Quantitative representation of positive intrarenal hypoxia inducible factor-1 (HIF-1𝛼) immunostaining/μm². Values are expressed as percentage ± SEM. 𝑛=5-6. ^∗𝑃<0.05 versus respective NS control; ^#𝑃<0.05 versus respective control without tempol. NS: normal salt diet group, HS: high salt diet group, NS-T: normal salt diet plus tempol group, HS-T: high salt diet plus tempol group. PT: proximal tubule, DT: distal tubule, CCD: cortical collecting duct, THAL: thick ascending limb of the loop of Henle, and MCD: medullary collecting duct.