Figure 1: Development of neointima in injured mouse arteries. Femoral arteries of adult male wild-type mice were injured by inserting large wires. Blood flow was restored and injured arteries were harvested at indicated time points. Small neointima is evident on luminal side of injured artery at one week after injury. Large neointima has grown on luminal side at three weeks after injury. Neointima and media at six weeks after injury contain very few CD45+ cells and neointima is predominantly composed of cells positive for α-SM actin. Arrowheads, internal elastic lamina. Bar, 20 μm.