Intrinsic Functional Connectivity Networks in Healthy Elderly Subjects: A Multiparametric Approach with Structural Connectivity Analysis
Figure 4
Effect of voxel-seed versus spherical ROI seeds at group level. (a) Default mode network (DMN) computed for a posterior cingulated cortex (PCC) seed. (b) Basal ganglia thalamic (BT) ICN computed for a caudate seed. Crosshairs on orthogonal slices indicate the voxel-seed location (left column), the center of the spherical ROI with 4 mm radius (center) and 10 mm radius (right). Data are shown in 1 mm cubic grid in the MNI space on the averaged MPRAGE image. The computation of the ICNs (right column of each pair) revealed similar results for a seed-voxel compared to a spherical ROI for the PCC seed (a). However, for smaller structures such as the caudate, the resulting brain map pointed towards a slightly different and more diffuse pattern with spherical radii larger than 4 mm (b).
