Heterogeneous Downregulation of Angiotensin II AT1-A and AT1-B Receptors in Arterioles in STZ-Induced Diabetic Rat Kidneys
Table 3
The relative numbers of angiotensin II AT1 receptor subtypes in the renin-negative and renin-positive SMCs in STZ-induced diabetic and normal rat kidney arterioles. The normal state in the number of AT1-B receptors between the renin-negative and renin-positive SMCs is changed to significantly different in diabetes, because of the enhanced downregulation of the AT1-B receptors in renin-positive SMCs.
Renin-positive SMCs
Renin-negative SMCs
Difference
Mean (CV)
Angiotensin II AT1-A receptors in afferent arterioles cells surface (signals/um3)
Normal
4
0.133 (0.42)
0.215 (0.18)
38%
0.026
Angiotensin II AT1-B receptors in afferent arterioles cells surface (signals/um3)
Normal
4
0.203 (0.34)
0.176 (0.11)
13.3%
NS
Angiotensin II AT1-A receptors in afferent arterioles cells surface (signals/um3)
Diabetic
5
0.0345 (0.52)
0.058 (0.31)
41%
0.035
Angiotensin II AT1-B receptors in afferent arterioles cells surface (signals/um3)
Diabetic
5
0.033 (0.45)
0.055 (0.16)
40%
0.0096
Angiotensin II AT1-(A + B) receptors in afferent arterioles cells surface (signals/um3)
Normal
4
0.156 (0.27)
0.216 (0.18)
27.8%
0.043
Angiotensin II AT1-(A + B) receptors in afferent arterioles cells surface (signals/um3)
