Genotoxicity of Microcystin-LR in In Vitro and In Vivo Experimental Models

Table 1

Results of DNA damage assessed by the comet assay (% of DNA in tail) in MCLR-treated Vero-E6 cells.

MCLR (𝜇M)	% of DNA in the comet tail
	Exposure time
	4 h		24 h
	Buffer	FPG	Buffer	FPG
0	4.11±0.21	5.13±0.28	3.29±0.01	3.76±0.42
5	4.21±0.38	4.96±0.42	3.16±0.39	3.37±0.14
10	3.82±0.04	6.41±0.55	2.74±0.44	4.08±0.21
20	4.77±0.50	5.74±0.75	3.67±0.16	4.22±0.14

Values are the mean (±SE) of three independent experiments. The percentage of DNA in the comet tail induced by the positive control (H₂O₂, 30 min) was 13.73±0.62 and 22.86±0.94, without and with FPG treatment, respectively.