Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel

Table 1

Number of differentially expressed genes (DEGs) comparing 16 mo and 3 mo animals residing solely in a cage (SED) or with access to an exercise wheel (EX), measured by gene array analysis on mRNA isolated from heart tissue.

Comparison group	Reference group	Total number of DEGs	Number of upregulated genes	Number of downregulated genes	Number of DEGs with >2-fold increase	>Number of DEGs with >2-fold decrease
SED; 16 mo	SED; 3 mo	228	123	105	23	15
EX; 16 mo	EX; 3 mo	230	133	97	19	20