Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel

Table 2

Common differentially expressed genes in SED and EX groups comparing 16 mo and 3 mo old animals.

Gene Symbol	Gene Name	Gene Function	Fold Change SED	Fold Change EX
col3a1	Collagen type III alpha 1	Connective tissue and vascular function	−1.5*	3.6^#
emb	Embigin	Cell growth and homeostasis	−1.7*	2.0^#
atp2b2	ATPase Calcium transporting plasma membrane 2	Intracellular calcium homeostasis	1.7^#	−8.9*
fmo1	Flavin containing monoxidase 1	Oxidative metabolism	1.8^#	−2.2*
cyp2e1	Cytochrome P450 family, 2, subfamily E polypeptide	Metabolism, cholesterol, and other lipid regulation	2.0^#	−1.6*
npr3	Natriuretic peptide receptor C/guanylate cyclase C	Regulates blood volume and pressure cardiac function, metabolism	2.0^#	2.3^#
nax4	NADPH oxidase 4	Generates superoxide, functions as an oxygen sensor, apoptosis	−2.1*	1.5^#
nadph oxidase 4	NADPH oxidase 4	Generates superoxide, functions as an oxygen sensor, apoptosis	−2.1*	−1.7*
inha	Inhibin alpha	Hypothalamic, pituitary, gonadal hormone secretion, germ cell development and maturation, erythoid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth	−2.6*	1.7^#
chrna1	Cholinergic receptor, nicotinic, alpha 1	Plays a role in acetylcholine binding/channel gating	4.0^#	2.3^#
cyp1a1	Cytochrome P450, family 1, subfamily A polypeptide 1	Drug metabolism and synthesis of cholesterol, steroids and other lipids, involved in an NADPH-dependent electron transport pathway	−4.1*	−1.6*

#: Up-regulation; *: down-regulation.