Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 951978, 6 pages
http://dx.doi.org/10.1155/2014/951978
Research Article

Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models

1Instituto de Biotecnología, CICVyA-INTA, N. Repetto and De los Reseros, 1686 Hurlingham, Argentina
2Public Health England, Porton Down, Salisbury SP4 0JG, UK
3Instituto de Patobiología, CICVyA-INTA, N. Repetto and De los Reseros, 1686 Hurlingham, Argentina

Received 10 October 2013; Revised 21 November 2013; Accepted 28 November 2013; Published 21 January 2014

Academic Editor: Jarosław Dziadek

Copyright © 2014 María V. Bianco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Biet, M. L. Boschiroli, M. F. Thorel, and L. A. Guilloteau, “Zoonotic aspects of Mycobacterium bovis and Mycobacterium avium-intracellulare complex (MAC),” Veterinary Research, vol. 36, no. 3, pp. 411–436, 2005. View at Publisher · View at Google Scholar
  2. M. A. Forrellad, L. I. Klepp, A. Gioffré et al., “Virulence factors of the Mycobacterium tuberculosis complex,” Virulence, vol. 4, no. 1, pp. 3–66, 2012. View at Publisher · View at Google Scholar
  3. A. Gioffré, E. Infante, D. Aguilar et al., “Mutation in mce operons attenuates Mycobacterium tuberculosis virulence,” Microbes and Infection, vol. 7, no. 3, pp. 325–334, 2005. View at Publisher · View at Google Scholar
  4. A. Williams, A. Davies, P. D. Marsh, M. A. Chambers, and R. G. Hewinson, “Comparison of the protective efficacy of bacille Calmette-Guérin vaccination against aerosol challenge with Mycobacterium tuberculosis and Mycobacterium bovis,” Clinical Infectious Diseases, vol. 30, supplement 3, pp. S299–S301, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. M. S. Lever, A. Williams, and A. M. Bennett, “Survival of mycobacterial species in aerosols generated from artificial saliva,” Letters in Applied Microbiology, vol. 31, pp. 238–241, 2000. View at Publisher · View at Google Scholar
  6. S. O. Clark, Y. Hall, D. L. F. Kelly, G. J. Hatch, and A. Williams, “Survival of Mycobacterium tuberculosis during experimental aerosolization and implications for aerosol challenge models,” Journal of Applied Microbiology, vol. 111, no. 2, pp. 350–359, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. M. Hartings and C. J. Roy, “The automated bioaerosol exposure system: preclinical platform development and a respiratory dosimetry application with nonhuman primates,” Journal of Pharmacological and Toxicological Methods, vol. 49, no. 1, pp. 39–55, 2004. View at Publisher · View at Google Scholar
  8. A. Williams, B. W. James, J. Bacon et al., “An assay to compare the infectivity of Mycobacterium tuberculosis isolates based on aerosol infection of guinea pigs and assessment of bacteriology,” Tuberculosis, vol. 85, no. 3, pp. 177–184, 2005. View at Publisher · View at Google Scholar
  9. A. Williams, G. J. Hatch, S. O. Clark et al., “Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis,” Tuberculosis, vol. 85, no. 1, pp. 29–38, 2005. View at Publisher · View at Google Scholar
  10. F. C. Blanco, M. V. Bianco, S. Garbaccio et al., “Mycobacterium bovis Δmce2 double deletion mutant protects cattle against challenge with virulent M. bovis,” Tuberculosis, vol. 93, no. 3, pp. 363–372, 2013. View at Publisher · View at Google Scholar