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BioMed Research International
Volume 2014 (2014), Article ID 957014, 21 pages
Review Article

Cellular Players in Skeletal Muscle Regeneration

1Department of Cell Biology and Histology, School of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania
2Department of Molecular Medicine and Neuroscience, “Victor Babes,” Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania
3Department of Neurology, Colentina Clinical Hospital (CDPC), School of Medicine, “Carol Davila” University of Medicine and Pharmacy, 19-21 Sos. Stefan cel Mare, 020125 Bucharest, Romania

Received 7 December 2013; Revised 12 January 2014; Accepted 28 January 2014; Published 23 March 2014

Academic Editor: P. Bryant Chase

Copyright © 2014 Laura Cristina Ceafalan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not yet controlled by any medical interventions. However, after thorough reports of their existence, survival, activation, and differentiation there are still many questions to be answered regarding the intimate mechanism of tissue regeneration. This review delivers an up-to-date inventory of the main known key players in skeletal muscle repair, revealed by various models of tissue injuries in mechanical trauma, toxic lesions, and muscular dystrophy. A better understanding of the spatial and temporal relationships between various cell populations, with different physical or paracrine interactions and phenotype changes induced by local or systemic signalling, might lead to a more efficient approach for future therapies.