Frequency and Clinical Implication of the R450H Mutation in the Thyrotropin Receptor Gene in the Japanese Population Detected by Smart Amplification Process 2
Table 1
Physical and laboratory characteristics of the participants.
Men
Women
Total
Reference range
Number
156
273
429
Age (years)
66.4 ± 10.8
63.2 ± 9.5
64.4 ± 10.1
<0.001
BMI (kg/m2)
23.4 ± 2.5
22.6 ± 2.9
22.9 ± 2.8
<0.001
TSH (U/mL)
1.60 ± 0.97
2.10 ± 2.63
1.92 ± 2.19
0.35–4.94
0.001
FT3 (pg/mL)
3.10 ± 0.46
3.11 ± 0.51
3.11 ± 0.49
1.71–3.71
0.897
FT4 (ng/dL)
1.04 ± 0.16
1.06 ± 0.16
1.05 ± 0.16
0.70–1.48
0.185
Positive cases of TgAb
25 (16.0%)
59 (21.6%)
84 (19.6%)
0.162
Positive cases of TPOAb
22 (14.1%)
41 (15.0%)
63 (14.7%)
0.797
Positive cases of antithyroid antibodies
34 (21.8%)
78 (28.6%)
112 (26.1%)
0.125
FT3: free 3,5,3′-triiodothyronine. FT4: free thyroxine. TgAb: antithyroglobulin antibody. TPOAb: antithyroid peroxidase antibody. Positive cases of antithyroid antibodies had TgAb and/or TPOAb. Data are expressed as mean ± standard deviation (SD). value was analyzed by comparing men with women.
