Reversal of Ampicillin Resistance in MRSA via Inhibition of Penicillin-Binding Protein 2a by Acalypha wilkesiana

Table 2

FIC indices of some combinations of ampicillin and 9EA-FC-B for MRSA.

Ampicillin (𝜇g mL^−1)	9EA-FC-B (mg mL^−1)
	1/4 × MIC (0.75)	1/8 × MIC (0.38)	1/16 × MIC (0.19)
1/2 × MIC (25)	0.75	0.65	0.56
1/4 × MIC (12.5)	0.43	0.36	0.31
1/8 × MIC (6.25)	0.38	0.25	—
1/16 × MIC (3.125)	0.31	0.19	—
1/32 × MIC (1.563)	0.28	—	—
1/64 × MIC (0.781)	—	—	—

Values represent triplicates of three independent experiments. Index interpretation: ≤0.5 = synergy, >0.5 but ≤4.0 = indifference, and >4 = antagonism. (MIC = minimum inhibitory concentrations; — = no activity.)