Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage

Table 4

Average DNA tail moment per cell stratified by MDR1 haplotypes.

Haplotype			Controls		Pesticide exposure				All
C3435T	G2677T/A	C1236T			Low		High
(rs1045642)	(rs2032582)	(rs1128503)	n *	Mean ± SE	n	Mean ± SE	n	Mean ± SE	n	Mean ± SE
T	T	C	83	1.25±0.02	51	2.24±0.07	68	2.13±0.05	202	1.79±0.04
C	G	C	65	1.26±0.02	43	2.19±0.07	57	2.17±0.05	165	1.81±0.04
C	G	T	56	1.30±0.02	34	2.16±0.08	41	2.08±0.06	131	1.77±0.05
x	A	x^#	43	1.31±0.03	26	2.07±0.09	37	2.18±0.06	106	1.80±0.05
Others^$			35	1.30±0.03	10	2.14±0.19	23	2.17±0.09	68	1.72±0.07

∗Number of alleles.
^#Haplotypes contained the variant A allele at the G2677T/A locus (including CAT, CAC, TAT, and TAC).
^$Rare haplotypes with frequencies <5% and not part of the variant A allele at the G2677T/A locus (including CTT, CTC, TGT, TGC, and TTT).