|
Reference number | Condition/disease | Species | Cell source of CM | Culture medium/culture type—condition | Cell number/application | Volume and mode of delivery | Outcome |
|
[6] |
Hind limb ischemia—direct |
Female athymic mice—20–25 gr |
Hu-AD-SC | αMEM—FBS 10%/monolayer—hypox 1% | 12.000 | 40 L—IM—7x | Good result |
CRM—Hu allo10%/spheroid—hypox 1% | 48.000 | Better result |
αMEM—FBS 10%/spheroid—hypox 1% | Better result |
|
[9] | Hind limb ischemia—10 days | Male NOD-SCID mice—10–12 weeks | Hu-AF-SC–Ckit (+) | αMEM—(−)/monolayer—normoxia | 500.000 | 80 L—IM—4x | Good result |
|
[11] | Full thickness wound—5 mm direct | Diabetic-immunodef. mice—17–23 g | Hu-UCB-CD34-EPC | M199 basal medium (−)/monolayer—normoxia | 1 × 106 | 100 L—intradermal injection | Good result |
|
[14] | Wound 30–50 mm2; 120–140 mm2—48 hours | Male NOD-SCID mice—4-5weeks | Hu-BM-MSC | αMEM—10% FBS/monolayer—normoxia | 1 × 108 | 100 L—SC—periphery wound | Good result |
|
[17] | MCI 48 hours | Nude-athymic rat—6–8 weeks | Hu-BM-MNC-stro-3-MPC | αMEM—(−)/monolayer—normoxia | 1 × 106 | 250 L Intramyocardial | Good result |
|
[20] | CCl4 injured acute hepatic failure—24 hours |
SCID-NOD mice—6–8 weeks | Hu-AF-MSC | DMEM—0.5% FBS/monolayer—normoxia | 1.5 × 106 | 200 L—intrahepatic (left liver lobe) | Good result |
Hu-AF-MSC- HPL | Better result |
|
[21] | Fulminant hepatic failure—24 hours | Male SD rat—250–300 g | Hu-MSC | DMEM—0.05% bovine serum albumin/monolayer—normoxia | 1.5 × 106 | 900 L penile vein | Good result Increased survival |
[22] | Male SD rat—280–370 g | Hu-BM-MSC | NA—0.05% BSA/monolayer—normoxia | 2 × 106 | 900 L CM Penile vein | Good result Increased survival |
|
[23] |
Focal cerebral ischemia—72 hours |
Male SD rat—350–400 g | Hu-EDT-SC | DMEM (−)/monolayer—normoxia | 400.000 | 10x10 µL—intranasal (left-right) Every day D3-D15 | Good result |
BM-MSC (Lonza) | Good result |
|
[24] | Ischemic Stroke—8 days | Male SD mouse—8 weeks | Hu-AD-MSC | αMEM—(−)/spheroid—hypoxia 1% | 50.400 | Infusion 0.5 µL/hour-7 days—lateral ventricle | Good result |
|