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BioMed Research International
Volume 2014, Article ID 971569, 10 pages
http://dx.doi.org/10.1155/2014/971569
Research Article

In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines

1Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India
2Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu 632 014, India
3Division of Industrial Biotechnology, School of Bio Sciences and Technology, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India

Received 19 February 2014; Revised 18 March 2014; Accepted 1 April 2014; Published 2 June 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 A. Bharathi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An in vitro antidiabetic activity on α-amylase and α–glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, 1H NMR, 13C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α-amylase and α-glucosidase.