Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells: Therapeutic Implication for the Men’s Cancer

Figure 5

The proposed mechanism underlying the inhibitory effect of MLN4924 in prostate cancer cells. MLN4924 inactivates CRLs by inhibiting cullin neddylation and thus induces accumulation of CRLs substrates. These consequently trigger a series of critical cellular effects including DNA damage response, G2 cycle arrest, and apoptosis, which are responsible for growth suppression of prostate cancer cells. DDR, DNA damage response.