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BioMed Research International
Volume 2014 (2014), Article ID 981923, 12 pages
http://dx.doi.org/10.1155/2014/981923
Research Article

Alkylation of Histidine Residues of Bothrops jararacussu Venom Proteins and Isolated Phospholipases : A Biotechnological Tool to Improve the Production of Antibodies

1Center of Applied Biomolecules Studies in Health (CEBio), Oswaldo Cruz Foundation (Fiocruz Rondônia), Porto Velho, RO, Brazil
2Department of Medicine, Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil
3Brazilian Institute of Environment and Renewable Natural Resources (IBAMA), Porto Velho, RO, Brazil
4Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil
5Department of Chemistry, Biotechnology and Bioprocess Engineering, Federal University of São João Del Rei (UFSJ), Ouro Branco, MG, Brazil
6Department of Molecular Biology, Center for Science and Nature, Federal University of Paraíba (UFPB), João Pessoa, Brazil
7Department of Clinical Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil
8Department of Physics and Biophysics, State University Paulista (UNESP), Botucatu, SP, Brazil
9Center for the Study of Venoms and Venomous Animals (CEVAP), State University Paulista (UNESP), Botucatu, SP, Brazil
10Institute for Research in Biomedicine (IRB Barcelona) and CIBER-BBN, Barcelona Science Park, Barcelona, Spain
11Department of Organic Chemistry, University of Barcelona, Barcelona, Spain
12School of Chemistry and Physics, University of KwaZulu Natal, Durban 4001, South Africa

Received 14 September 2013; Accepted 2 January 2014; Published 11 May 2014

Academic Editor: Edward G. Rowan

Copyright © 2014 C. L. S. Guimarães et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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