Review Article
Fluid Resuscitation in Sepsis: Reexamining the Paradigm
Table 1
Summary of studies evaluating crystalloids.
| Author | Year | Study design | Sample size | Study fluid | Primary endpoint | Comments |
| Wilcox [45] | 1983 | Animal experiment | 48 | Chloride rich solutions | Regulation of renal blood flow | Increased renal vasoconstriction and GFRa with chloride rich solutions |
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Waters et al. [49] | 2001 | Prospective randomized study | 66 | 0.9% Saline versus lactated Ringer | Multiple outcomes studied | Increased use of blood products and acidosis with 0.9% Saline |
| O’Malley et al. [50] | 2005 | Randomised clinical trial | 51 | 0.9% Saline versus lactated Ringer | Creatinine concentration on POD3b | No difference; but Ringer’s was associated with less hyperkalemia and acidosis |
| Shaw et al. [51] | 2012 | Observational | 31,920 | 0.9% Saline versus balanced crystalloid | Major morbidity | Higher mortality, increased transfusion requirements, dialysis requirements, and increased buffer requirements in saline group |
| Maitland et al. [52] | 2011 | Multicentric randomized trial | 3141 | Albumin bolus and saline bolus | Mortality | Boluses resulted in increased mortality |
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Table summarizing studies evaluating crystalloids. aGlomerular Filtration Rate, bPostoperative Day 3.
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