Fluid Resuscitation in Sepsis: Reexamining the Paradigm

Table 2

Summary of studies evaluating colloids.

Author	Year	Study design	Sample size	Study fluid	Primary endpoint	Comments
Schierhout and Roberts [55]	1998	Meta-analysis	1315	All colloids	Mortality	Increased mortality
Laxenaire et al. [56]	1994	Multicentre prospective	19593	All colloids	Adverse effects	Gelatins and dextrans-independent risk for anaphylactoid reactions
Myburgh et al. [61]	2012	RCT^a	7000	HES^b versus 0.9% saline	90-day mortality	HES^b associated with increased incidence of RRT
Perner et al. [62]	2012	RCT^a	804	HES^b versus Ringer’s acetate	Death/dialysis dependence at 90 days	Death and dialysis dependence more in HES
Zarychanski et al. [63]	2013	Meta-analysis	10,290	HES^b	Mortality and AKI^c	Significant increase in risk of mortality and AKI^c
Guidet et al. [64]	2012	RCT^a	196	HES^b versus 0.9% saline	Hemodynamic efficacy and safety	HES^b better hemodynamic efficacy and no difference in AKI^c
Finfer et al. [67]	2004	RCT^a	6997	Albumin versus 0.9% saline	28-day mortality	No difference
Myburgh et al. [72]	2007	Post hoc analysis of SAFE trial	460	Albumin versus 0.9% saline	Safety in TBI^d	Albumin unsafe for TBI^d
Delaney et al. [68]	2011	Meta-analysis	1977	Albumin	Safety for resuscitation	Albumin associated with lower mortality
Annane et al. [69]	2013	RCT^a	2857	Colloids versus crystalloids	28-day mortality	No difference

Table summarizing studies evaluating colloids. ^aRandomized Controlled Trial, ^bHydroxyethyl starch, ^cAcute Kidney Injury, ^dTraumatic Brain Injury.