Solid-Nanoemulsion Preconcentrate for Oral Delivery of Paclitaxel: Formulation Design, Biodistribution, and γ Scintigraphy Imaging

Table 1

Observation of different composition of nanoemulsion preconcentrate for thermodynamic stability, dispersibility, percentage transmittance, and rate of emulsification.

Formulation	Composition; [oil : surfactant : cosurfactant] (𝜇L)	Centrifugation cycle	Heating-cooling cycle	Freeze-thaw cycle	Dispersibility test		Percentage transmittance	Emulsification; rate (sec)
					0.1 N HCl	Distilled water
S1	175 : 300 : 225	√	√	√	Grade A	Grade A	92.05	30
S2	225 : 250 : 175	√	x	x	Grade B	Grade B	76.23	45
S3	200 : 350 : 125	√	√	√	Grade A	Grade A	89.43	52
S4*	175 : 350 : 175	√	√	√	Grade A	Grade A	99.55	38
S5	200 : 300 : 175	√	√	√	Grade B	Grade B	85.34	42
S6	175 : 300 : 125	√	√	√	Grade A	Grade A	87.91	47
S7	225 : 300 : 125	√	√	√	Grade B	Grade B	82.67	50
S8	175 : 250 : 175	√	√	√	Grade B	Grade B	84.18	35
S9	225 : 350 : 175	√	√	√	Grade B	Grade B	87.31	46
S10	200 : 250 : 125	√	√	√	Grade B	Grade B	75.84	44
S11	200 : 250 : 225	√	√	√	Grade B	Grade B	76.09	40
S12	225 : 300 : 225	√	√	√	Grade B	Grade B	81.49	48
S13	200 : 350 : 225	√	√	√	Grade A	Grade A	97.06	40

∗Indicates optimized formulation.