Research Article

Arrabidaea chica Hexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition on Leishmania spp.

Figure 1

Inhibitory activity of the B2 fraction obtained from the A. chica hexanic extract on Leishmania peptidases. (a) Peptidase inhibitory activity at pH 5.5; (b) peptidase inhibitory activity at pH 10. 2xMIC, MIC, and subMIC values for L. amazonensis and L. infantum were 74.4, 37.2, and 18.6 μg/mL and 37.2, 18.6, and 9.3 μg/mL, respectively.