Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus
α-AA effect on the NMDA-induced hippocampal lesion. Photomicrographs of cresyl-violet stained brain sections of sham rats. (a) NMDA rats 15 days (b) and 38 days after the lesion (c). α-AA rats (d) and α-AA + NMDA rats 15 days (e) and 38 days after the lesion (f). Asterisks indicate the injection site. Graphs (g) to (i) show the quantification of the area of neuronal loss in cresyl-violet stained sections in the pyramidal CA1 (g), pyramidal CA2-CA3 (h), and dorsal dentate gyrus (i) of sham (PBS), α-AA, NMDA, and α-AA + NMDA rats at postlesion days 1, 3, 15, and 38. Graphs (j) to (l) show the estimation of the density NeuN immunopositive neurons in the pyramidal CA1 (j), pyramidal CA2-CA3 (k), and dorsal dentate gyrus (l) of the same rats. different from PBS; # different from NMDA (LSD post hoc test) ( rats/group). Bar: 500 μm.
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