BioMed Research International / 2015 / Article / Tab 1

Research Article

Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus

Table 1

[3H]11195 and [3H]corticosterone specific binding to brain sections after 20 nmol NMDA injection in the hippocampus.

0 days1 day 5 days 15 days 38 days

Specific TSPO binding
 Sham hippocampus 481 ± 98 1532 ± 107#618 ± 187 483 ± 341 483 ± 102
 NMDA hippocampus 480 ± 73 1495 ± 189*1644 ± 255*#1571 ± 346*#1440 ± 235*#
 Parietal cortex 490 ± 11 474 ± 64 472 ± 40 473 ± 18 488 ± 9
 Piriform cortex 468 ± 5 439 ± 35 425 ± 33 453 ± 37 465 ± 2
Specific GR binding
 Sham hippocampus 68 ± 72 101 ± 94 74 ± 37 81 ± 13 75 ± 21
 NMDA hippocampus 76 ± 62 198 ± 104 448 ± 247*#91 ± 23 105 ± 32
 Parietal cortex 101 ± 19 102 ± 14 85 ± 19 77 ± 32 102 ± 20
 Piriform cortex 103 ± 24 74 ± 19 89 ± 6 73 ± 3 102 ± 42

18 kDa translocator protein (TSPO) concentration was estimated by [3H]PK11195 specific binding. 5 M RU-28362 allowed discriminating the [3H]corticosterone specific binding to glucocorticoid receptors (GR). Data are expressed in fmol/mg of protein (mean ± S.E.M). * different from 0 days; # different from sham values (KW test).

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