Astroglia-Microglia Cross Talk during Neurodegeneration in the Rat Hippocampus
Table 1
[3H]11195 and [3H]corticosterone specific binding to brain sections after 20 nmol NMDA injection in the hippocampus.
0 days
1 day
5 days
15 days
38 days
Specific TSPO binding
Sham hippocampus
481 ± 98
1532 ± 107#
618 ± 187
483 ± 341
483 ± 102
NMDA hippocampus
480 ± 73
1495 ± 189*
1644 ± 255*#
1571 ± 346*#
1440 ± 235*#
Parietal cortex
490 ± 11
474 ± 64
472 ± 40
473 ± 18
488 ± 9
Piriform cortex
468 ± 5
439 ± 35
425 ± 33
453 ± 37
465 ± 2
Specific GR binding
Sham hippocampus
68 ± 72
101 ± 94
74 ± 37
81 ± 13
75 ± 21
NMDA hippocampus
76 ± 62
198 ± 104
448 ± 247*#
91 ± 23
105 ± 32
Parietal cortex
101 ± 19
102 ± 14
85 ± 19
77 ± 32
102 ± 20
Piriform cortex
103 ± 24
74 ± 19
89 ± 6
73 ± 3
102 ± 42
18 kDa translocator protein (TSPO) concentration was estimated by [3H]PK11195 specific binding. 5 M RU-28362 allowed discriminating the [3H]corticosterone specific binding to glucocorticoid receptors (GR). Data are expressed in fmol/mg of protein (mean ± S.E.M). * different from 0 days; # different from sham values (KW test).
