Research Article

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Figure 5

Expression of nephrin is reduced in the glomeruli of E1-DN mice. ((a), (b)) Confocal microscopy of wild-type (wt) (a) and homozygous (hoz) (b) E1-DN mouse kidney sections stained for nephrin. (c) Quantification of the expression level of nephrin in two wild-type mice and three albuminuric homozygous mice, five glomeruli per mice, reveals that the expression of nephrin is significantly lower in the E1-DN homozygous mice. Bars show mean ± SEM. , Student’s -test. Scale bar: 20 μm.
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