Characterization of hOFs in comparison with hDFs and hOF-iPSCs. (a) Strategy to define the characteristics of hOFs. The differentially expressed gene groups between hOFs and hDFs were rearranged by the expression similarity with hOF-iPSCs. The readout for hOFs indicates the characteristics of hOFs. Each gene in G1–G4 is listed in Supplementary Tables S4–S7, respectively. (b) The characterization of each gene group categorized in (a). Numbers indicate the percentage of gene numbers in the individual categories compared with total numbers. The groups colored in yellow show the molecules receiving environmental stimuli. The groups colored in pink represent molecules involved in controlling cell fate. (c) The list of individual transcriptional regulators found in (b). Each indicated number is the average signal value in each cell type. (d) Expression levels of reprograming enhancers among the three cell types. Each indicated number is the average signal value in each cell type. Red: hOFs > hDFs > hOF-iPSCs; blue: hOFs = hDFs > hOF-iPSCs. The full names of each gene listed in (d) are shown in Supplementary Table S8.