Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells

Figure 5

Summary of gene signatures in hOFs. (a) Overview of gene profiles in oral mucosal fibroblasts. Dotted-lined box indicates the category of genes. Red- and blue-colored words in italics show the biological function of gene categories with high and low expressions, respectively. (b) A proposed possible gene network in oral mucosal fibroblasts. Gene names in the different color are indicated as follows. Red: high expression in hOFs compared with that in hDFs (hOFs > hDFs); blue: low expression in hOFs compared with that in hDFs (hOFs < hDFs); purple: similar expression in hOFs and hDFs, but higher than hiPSCs (hOFs = hDF > hiPSCs). The box colors indicate biological characteristics or functions as follows. Pink box: possible “plastic” characteristics; green box: possible “specific” characteristics of hOFs; gray box: WNT signal regulators; lined box: biological function; dotted-lined box: the known key transcription factors. Dotted bar indicates indirect effect. Detailed explanations of (a) and (b) are described in the text.

(a)

(b)