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BioMed Research International
Volume 2015, Article ID 121973, 14 pages
Review Article

Detecting Blood Flow Response to Stimulation of the Human Eye

Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA

Received 29 May 2015; Accepted 10 September 2015

Academic Editor: Keisuke Mori

Copyright © 2015 Alex D. Pechauer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Retinal blood supply is tightly regulated under a variety of hemodynamic considerations in order to satisfy a high metabolic need and maintain both vessel structure and function. Simulation of the human eye can induce hemodynamics alterations, and attempt to assess the vascular reactivity response has been well documented in the scientific literature. Advancements in noninvasive imaging technologies have led to the characterization of magnitude and time course in retinal blood flow response to stimuli. This allowed for a better understanding of the mechanism in which blood flow is regulated, as well as identifying functional impairments in the diseased eye. Clinically, the ability to detect retinal blood flow reactivity during stimulation of the eye offers potential for the detection, differentiation, and diagnosis of diseases.