Research Article

Proteomic Study to Survey the CIGB-552 Antitumor Effect

Table 1

Proteins identified by chemical proteomics as potential CIGB-552 targets.

UniProt ACCDescriptionGene symbolScoreemPAI

O95218Zinc finger Ran-binding domain-containing protein 2ZRANB2390.21
Q9NX65Zinc finger and SCAN domain-containing protein 32ZSCAN32260.05
Q9UBQ0Vacuolar protein sorting-associated protein 29VPS29560.66
Q14376UDP-glucose 4-epimerase GALE380.1
Q12888Tumor suppressor p53-binding protein 1TP53BP1280.02
O14773Tripeptidyl-peptidase 1TPP1760.06
Q13428Treacle proteinTCOF1270.02
P04183Thymidine kinase, cytosolicTK1240.15
Q9NXG2THUMP domain-containing protein 1THUMPD1580.09
Q8WW59SPRY domain-containing protein 4SPRYD4390.16
P63151Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPPP2R2A870.07
Q9NVA2Septin-11SEPT11290.08
O00764Pyridoxal kinasePDXK590.11
Q16740ATP-dependent Clp protease proteolytic subunit, mitochondrialCLPP670.26
Q9Y4X5E3 ubiquitin-protein ligase ARIH1ARIH1290.06
O15460Prolyl 4-hydroxylase subunit alpha-2P4HA2410.12
P40261Nicotinamide N-methyltransferaseNNMT460.27
P19105Myosin regulatory light chain 12AMYL12A2002.45
Q16539Mitogen-activated protein kinase 14MAPK14820.19
Q9UNF1Melanoma-associated antigen D2MAGED22380.18
P50213Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIDH3A640.2
P05161Ubiquitin-like protein ISG15ISG15340.21
O00629Importin subunit alpha-3KPNA4490.06
Q8WTS6Histone-lysine N-methyltransferase SETD7SETD7420.09
P06737Glycogen phosphorylase, liver formPYGL400.04
P30712Glutathione S-transferase theta-2GSTT2960.14
P47755F-actin-capping protein subunit alpha-2CAPZA21090.38
P52907F-actin-capping protein subunit alpha-1CAPZA11180.54
P41091Eukaryotic translation initiation factor 2 subunit 3EIF2S3430.07
O95571Persulfide dioxygenase ETHE1, mitochondrialETHE1350.13
Q9BVJ7Dual specificity protein phosphatase 23DUSP23500.23
P52564Dual specificity mitogen-activated protein kinase kinase 6MAP2K6290.1
Q14691DNA replication complex GINS protein PSF1GINS1240.16
Q3LXA3Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)DAK450.06
P21291Cysteine and glycine-rich protein 1CSRP1470.39
Q99627COP9 signalosome complex subunit 8COPS8690.35
Q9UBW8COP9 signalosome complex subunit 7aCOPS7A460.12
P61201COP9 signalosome complex subunit 2COPS21360.23
Q07021Complement component 1 Q subcomponent-binding protein, mitochondrialC1QBP6481.74
Q9NT62Ubiquitin-like-conjugating enzyme ATG3ATG3580.1
Q9BZZ5Apoptosis inhibitor 5API51730.13
P12814Alpha-actinin-1ACTN113451.76
P11766Alcohol dehydrogenase class 3ADH5780.19
P36404ADP-ribosylation factor-like protein 2ARL2380.4
P40616ADP-ribosylation factor-like protein 1ARL1390.19
P84077ADP-ribosylation factor 1ARF1990.66
P00813Adenosine deaminaseADA350.09
Q9BTT0Acidic leucine-rich nuclear phosphoprotein 32 family member EANP32E1690.41
P8409860S ribosomal protein L19RPL19380.16
P61586Transforming protein RhoARHOA320.17
Q07960Rho GTPase-activating protein 1ARHGAP1630.07
Q14657EKC/KEOPS complex subunit LAGE3LAGE3340.26
Q96IU4Alpha/beta hydrolase domain-containing protein 14BABHD14B670.17
P39687Acidic leucine-rich nuclear phosphoprotein 32 family member AANP32A2861.38
O75607Nucleoplasmin-3NPM3330.2

UniProtKB/Swiss-Prot entry accession number (http://www.uniprot.org/).
Recommended gene name (official gene symbol) as provided by UniProtKB/Swiss-Prot.
MASCOT protein score.
emPAI: exponentially modified Protein Abundance Index.