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BioMed Research International
Volume 2015, Article ID 125807, 10 pages
http://dx.doi.org/10.1155/2015/125807
Review Article

Role of Exosomal Noncoding RNAs in Lung Carcinogenesis

1Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China
2Department of Perinatal Medicine, Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women’s Hospital, Parkville, VIC 3052, Australia
3Emergency Department of Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430010, China
4Department of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China

Received 17 April 2015; Revised 5 July 2015; Accepted 16 July 2015

Academic Editor: Denis Corbeil

Copyright © 2015 Tao Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology.