BioMed Research International / 2015 / Article / Tab 2 / Review Article
Role of Exosomal Noncoding RNAs in Lung Carcinogenesis Table 2 The potential mechanisms of lncRNAs in lung cancer.
Onco-lncRNA Potential mechanism Reference MVIH Affects expression of MMP-2/MMP-9 Proliferation and invasion [89 ] BC200 Upregulated in lung cancer [90 ] lncRNA-DQ786227 Upregulated in lung cancer [91 ] MALAT1 Affects expression of Bcl-2 and metastasis related genes [92 ] AK126698 Decreases NKD and increases the accumulation and nuclear translocation of β -catenin Antiapoptotic effects and resistance to cisplatin [93 ] SCAL1 Induced by cigarette smoke and NRF2 Protective against oxidative stress [94 ] HOTAIR Induced by Col-1 upregulation of cell adhesion-related genes such as ASTN1 and PCDHA1 Downregulates genes involved in neuronal growth and signal transduction including NTM and PTK2B Contributes to the cisplatin resistance through the regulation of p21 expression Affects proliferation, migration, and invasion [95 –97 ] Tumor suppressor lncRNA Potential mechanism Reference BANCR A regulator of EMT during NSCLC Induces apoptosis and inhibits EMT, migration, invasion, and metastasis [98 ] MEG3 Inhibits NSCLC cell proliferation and induces apoptosis by affecting p53 expression [99 ] SPRY4-IT1 Promotes NSCLC cell proliferation and metastasis via effects on the epithelial-mesenchymal transition [100 ] TUG1 Affects cell proliferation in human NSCLC through epigenetically regulating HOXB7 expression [101 ]