Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents

Figure 7

Summary schematic of opioid-induced cardioprotection. Opioids reduce myocardial infarct size through δ-opioid receptors (DOR) and sarcolemmal channels. Subsequent activation of phosphoinositol-3 kinase (PI3k), protein kinase B (AKT), target of rapamycin (mTOR), JAK2, and STAT3 occur upstream of GSK3β inhibition. From this study, HSP90 is important for regulating opioid-induced cardioprotection, partially downstream of GSK3β inhibition. GSK3β likely regulates mitochondrial import through the HSP90 complex with TOM70.