In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain

Figure 6

In vivo MR imaging of endogenous NSCs. Serial sagittal -weighted images showed that linear (arrows) and spotty hypointense signal (arrowheads) appear in the beginning of RMS and SVZ and in animals injected with anti-CD15-SPIONs (a); these hypointense signal patterns persist to 3 days after injection and are almost invisible by 7 days and disappear by 10 days after injection. No such developing signal intensity is found in the SVZ and RMS in animals injected with nontargeted SPIONs (b) or mAb (c) or PBS (d) alone.

(a)

(b)

(c)

(d)