Biochemical and Functional Comparisons of mdx and Sgcg^−/− Muscular Dystrophy Mouse Models

Figure 4

The Sgcg^−/− D2 muscles demonstrated significantly increased membrane permeability at 12 weeks old. (a) Sgcg^−/− D2 mice showed statistically higher EBD in their Quadriceps at 12 weeks compared to the mdx mice. (b) Sgcg^−/− D2 mice showed statistically higher EBD in their Triceps-Brachii at 12 weeks compared to the mdx mice. (c) Sgcg^−/− D2 showed statistically higher EBD in their Gastrocnemius and Soleus at 8 and 12 weeks compared to the mdx mice. (d) Sgcg^−/− D2 Gluteus and Hamstrings showed higher EBD than the mdx mice at 8, 12, and 16 weeks. significance versus Sgcg^−/− D2 animals. Sgcg^+/+ D2 at 4, 12 weeks , all others –15.

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