Research Article

Biochemical and Functional Comparisons of mdx and Sgcg−/− Muscular Dystrophy Mouse Models

Figure 5

The Sgcg−/− D2 muscles were consistently more fibrotic than the age matched mdx mice by hydroxyproline assay. Sgcg−/− D2 mice showed significantly higher levels of Quadriceps fibrosis at 12 and 16 weeks versus the mdx mice and significantly more fibrosis than their Sgcg+/+ D2 controls at 16 weeks. Sgcg−/− D2 mice had significantly higher fibrosis content in their Triceps-Brachii at all-time points compared to the mdx mice. At 12 weeks Sgcg−/− D2 mice have higher fibrosis content than the mdx mice in their Gastrocnemius/Soleus muscles. A similar pattern was seen in the Gluteus/Hamstring muscle group, and the Sgcg−/− mice had significantly higher fibrosis content at 12 weeks than the mdx mice. Sgcg−/− mice showed greater collagen content at 4, 8, and 12 weeks compared to the mdx mice. Additionally the Sgcg+/+ mice had higher collagen content than the Sgcg−/− mice at 16 weeks. , significance versus Sgcg−/− D2 animals. Sgcg+/+ D2 at 4 and 12 weeks ; Sgcg+/+ D2 at 8 weeks ; all others –16.
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