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BioMed Research International
Volume 2015, Article ID 131685, 13 pages
Research Article

Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal
2ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Campus of Gualtar, 4710-057 Braga, Portugal
3Surgery Department, Hospitalar Center Trás-os-Montes e Alto Douro, Unidade Hospitalar de Chaves, Avenida Dr. Francisco Sá Carneiro, 5400-279 Chaves, Portugal
4Pathology Department, Braga Hospital, Sete Fontes, São Victor, 4710-243 Braga, Portugal
5Coloproctology Unit, Braga Hospital, Sete Fontes, São Victor, 4710-243 Braga, Portugal
6Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of Sao Paulo, 01246-903 São Paulo, SP, Brazil
7Molecular Oncology Research Centre, 14784-400 Barretos, SP, Brazil

Received 4 December 2014; Accepted 2 February 2015

Academic Editor: Konstantinos Arnaoutakis

Copyright © 2015 Sandra F. Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.